03 06 08

Monsanto Company and Divergence announced today they have completed the most comprehensive sequence of the soybean cyst nematode (SCN) genome to date, making it the first available draft of this organism’s genome. Today’s announcement by the companies represents a major advancement in the available research data on this crop pest.

Certain nematode species severely limit crop yields around the world, including in crops such as soybeans, corn, cotton, and vegetables. SCN attacks roots of soybeans during the growing season and today represents the most economically significant pest for U.S. soybean production. It is estimated that SCN annually causes approximately $1 billion of yield loss to the US soybean crop.

“Sequencing the SCN genome is a tremendous step forward in our process of developing a product to help farmers protect their soybean crops against a devastating pest,” said Steve Padgette, Monsanto vice president of biotechnology. “As global demand for soy protein increases, it is critical that companies evaluate and invest in novel approaches to combat this yield-robbing pest so farmers can get more yield out of every acre.”

The companies announced that the genome sequence will be made available to the public via the National Center for Biotechnology Information (NCBI) website. Interested parties can access this information at http://www.ncbi.nlm.nih.gov/.

NCBI creates public databases that house information like genome sequences to facilitate better understanding of molecular processes. The companies believe the sharing of this data, subject to Monsanto and Divergence intellectual property rights, will be an important step forward in research on this parasite.

“We anticipate that sharing this sequence on the NCBI database will spur additional innovation in the scientific community to develop tools to help farmers manage this pest on their farm,” said Padgette.

"The SCN genome is the first available for any plant parasitic nematode," said James McCarter, president and chief scientific officer of Divergence. "This draft assembly, based on three-fold sequence coverage of the genome, provides key insights into the molecular mechanisms that enable SCN to invade and drain nutrients from soybean roots."

Monsanto and Divergence entered into a collaborative relationship in 2004 to discover novel approaches for controlling SCN, and extended the relationship in 2007. Monsanto scientists worked together with Divergence to sequence the SCN genome as part of this collaboration.

About Monsanto

Monsanto Company is a leading global provider of technology-based solutions and agricultural products that improve farm productivity and food quality. To learn more, please visit www.monsanto.com.

About Divergence

Divergence is dedicated to the discovery of effective and ecologically sound strategies for the control of parasites and other pests. The company's initial focus is on parasitic nematodes, one of the world's major pest groups. Nematodes are roundworms that cause billions of dollars in damage annually to numerous crops, including soybeans, cotton, strawberries, and bananas. Nematodes also cause widespread disease in animals, including infections such as heartworm in dogs and cats and intestinal worms in livestock. Nematode-induced human diseases include elephantiasis and African river blindness. To learn more, please visit www.divergence.com.

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