Biotech Possibilities Draw Top Talent from Coasts

Rachel Melcer
Of The Post-Dispatch

St. Louis hopes to build on the growing pool of transplanted executives -- serial entrepreneurs who get businesses off the ground and then move on -- drawn to the area by the culture, the lower cost of living and the budding urban renewal.

One by one, successful biotech entrepreneurs from the coasts are moving to St. Louis, lured by a honey of a deal here or a sweet bit of technology there. And the buzz is beginning to build.

They carry the business sense and experience that could pollinate St. Louis startups and help them to grow, say investors and biotech boosters. They have been there, done that in New York and San Diego, San Francisco and Boston. And they hope to do it again -- here.

"It's a very supportive environment," said Laurent Fischer, president and chief executive of Auxeris Therapeutics Inc., which last week moved into the Center for Emerging Technologies incubator. "But (St. Louis) needs to be better known. It's starting to happen."

Fischer, who is house-hunting in the Central West End and other areas, recently helped to launch San Diego-based Medvantx Inc. Before that, he was president of RXCentric.com Inc. in New York.

He is what most startups and investors want: a serial entrepreneur who knows how to get a business off the ground and then move on.

The St. Louis Regional Chamber & Growth Association hopes to find more like him on a recruiting trip to California in the spring. It will take entrepreneurs on tour to tout this area and its biotech potential, said Ri chard Fleming, RCGA president and chief executive.

"Increasingly, economic development is not just about recruiting companies, but about recruiting talent," he said. "There's an analogy to the sports world: When you're building a team, you do that through a combination of talent coming up through your farm system, as well as recruiting free agents from other teams who have already established their careers."

The RCGA hopes to build on the growing, but still small, pool of transplanted executives who said they were drawn to St. Louis by the culture, lower cost of living and budding urban renewal that remind them of their former Boston and Bay Area homes, 20 or 30 years ago.

"There's a lot of money; there's a lot of technology. But it's very conservative," said Ben Brink, chief executive of APMaterials, a startup in the CET. A St. Louis native, he had been living the high-tech life in San Francisco but returned about a year ago for the quality of life and burgeoning entrepreneurial opportunities.

"There are a lot of me in the Bay Area, (but) there aren't a lot of people in St. Louis yet who have the kind of experience that I do," he said.

That's a problem for venture-capital investors, who are enticed by local opportunities but want to make sure their millions are in good hands. So they, too, are taking action.

"Most of the pieces are here for staffing out an organization from the science side. . . . But what has been missing is senior entrepreneurial leadership," said Mark Mendel, managing director of Clayton-based RiverVest Venture Partners.

RiverVest, along with Domain Associates LLC of Princeton, N.J., invested $2.5 million in Auxeris last fall. Then the Clayton firm recruited Fischer from among candidates from all over the country, Mendel said.

Leaders at CET and the area's other biotech incubator, the Nidus Center for Scientific Enterprise, say they are encouraged by the incoming talent at companies such as Kereos and Nudisco, MicroSense and Stereotaxis. They can fill gaps while home-grown entrepreneurs get going and provide advice along the way.

Marcia Mellitz, president of the CET, said: "These (early-stage) companies have often been created by a scientist or an engineer who's a great creative person but may not be the best business person."

And while St. Louis is rich in people with corporate experience from careers with Monsanto, Boeing and the like, many lack entrepreneurial skills.

To run a startup, "You need a technology background and a business background," Brink said. "You need to be a generalist, comfortable running all aspects of a little company, because you don't have a lot of help. . . . You need a good understanding of your strengths and weaknesses and must be willing to hire somebody who's smarter than you. (And) you need to have a strong tolerance for stomach acid."

Entrepreneurs know that not every startup will succeed, but that alone doesn't dissuade them, said Bob Calcaterra, Nidus Center president. They will come if their failures will be regarded as learning experiences along with their successes - and if there are other opportunities available.

"That's the concern. It's, 'Gee, what if I come here and this thing tanks? If I uproot my family and come here, what are the chances that I'll find something else quickly?'" Calcaterra said. "And that's a legitimate concern, because we don't (yet) have that critical mass where they can just walk down the street and find another job."

Brink, who plans to participate in the RCGA recruiting tour, shares these concerns but is hopeful.

"To move people from an entrepreneurial area to a non-entrepreneurial area, they need to know that they've got a real opportunity to get a company to run," he said. "People who run companies aren't very good at waiting around and wearing holes in the carpet."


Published in the Business section of the St. Louis Post-Dispatch on February 11, 2003.
Copyright (C)2003, St. Louis Post-Dispatch

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